Proteins/UNIPROT:Q9UJV3

MID2

ProteinUNIPROT:Q9UJV3

E3 ubiquitin-protein ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29..

Function from UniProtKB (Q9UJV3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

non-syndromic X-linked intellectual disability has a germline basis in MID2DiseaseGenCC HGNC:7096|MONDO:0019181Inferred only

Statements

27 statements

27 statements · 2 reference databases · Subject: MID2 · Sources: gene ontology, Hetionet

Order

MID2 covaries with APLP1ProteinHetionet hetionet:covaries:11043-333Inferred only
MID2 covaries with PRICKLE3ProteinHetionet hetionet:covaries:11043-4007Inferred only
MID2 covaries with SEMA4FProteinHetionet hetionet:covaries:10505-11043Inferred only
MID2 interacts with CEP57L1ProteinHetionet hetionet:interacts:11043-285753Inferred only
COX5B interacts with MID2ProteinHetionet hetionet:interacts:11043-1329Inferred only
MID2 interacts with DYDC1ProteinHetionet hetionet:interacts:11043-143241Inferred only
GFI1B interacts with MID2ProteinHetionet hetionet:interacts:11043-8328Inferred only
GJA1 interacts with MID2ProteinHetionet hetionet:interacts:11043-2697Inferred only
IGBP1 interacts with MID2ProteinHetionet hetionet:interacts:11043-3476Inferred only
MID1 interacts with MID2ProteinHetionet hetionet:interacts:11043-4281Inferred only
MID2 interacts with TMEM14BProteinHetionet hetionet:interacts:11043-81853Inferred only
MID2 interacts with TRIM29ProteinHetionet hetionet:interacts:11043-23650Inferred only

Show the remaining 15

MID2 interacts with TRIM32ProteinHetionet hetionet:interacts:11043-22954Inferred only
MID2 interacts with TSGA10ProteinHetionet hetionet:interacts:11043-80705Inferred only
UBC interacts with MID2ProteinHetionet hetionet:interacts:11043-7316Inferred only
UBE2D1 interacts with MID2ProteinHetionet hetionet:interacts:11043-7321Inferred only
UBE2D2 interacts with MID2ProteinHetionet hetionet:interacts:11043-7322Inferred only
UBE2D3 interacts with MID2ProteinHetionet hetionet:interacts:11043-7323Inferred only
MID2 interacts with UBE2D4ProteinHetionet hetionet:interacts:11043-51619Inferred only
UBE2E1 interacts with MID2ProteinHetionet hetionet:interacts:11043-7324Inferred only
UBE2E2 interacts with MID2ProteinHetionet hetionet:interacts:11043-7325Inferred only
UBE2E3 interacts with MID2ProteinHetionet hetionet:interacts:10477-11043Inferred only
UBE2N interacts with MID2ProteinHetionet hetionet:interacts:11043-7334Inferred only
MID2 interacts with UBE2UProteinHetionet hetionet:interacts:11043-148581Inferred only
ZNF24 interacts with MID2ProteinHetionet hetionet:interacts:11043-7572Inferred only
MID2 regulates positive regulation of autophagyBiological processgene ontology Q9UJV3|GO:0010508Inferred only
MID2 regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q9UJV3|GO:0043123Inferred only

Other names

9 names

Resolves to: MID2

Also called: FXY2Midin-2Midline defect 2Midline-2RING finger protein 60RING-type E3 ubiquitin transferase MID2RNF60TRIM1Tripartite motif-containing protein 1

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