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Proteins/UNIPROT:O43451
Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry. Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues. Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed..
Function from UniProtKB (O43451), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
38 statements
38 statements · 7 reference databases · Subject: MGAM · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
16 reactions
water+alpha-D-glucosyl-(1->4)-alpha-D-mannose2D-glucose
Catalysed by GAA or GANC or MGAM
Reaction pageLeft to rightBalancedEC 3.2.1.20extracellular space
Human-GEM MAR03989CC BY 4.0Reference data
3 names
Resolves to: MGAM
Reaction pageLeft to rightBalancedEC 3.2.1.10, 3.2.1.20, 3.2.1.48extracellular space
Human-GEM MAR04303CC BY 4.0Reference data
8water+MAM02936e8D-glucose+MAM02937e
Catalysed by MGAM
Reaction pageLeft to rightBalancedEC 3.2.1.3extracellular space
Human-GEM MAR08583CC BY 4.0Reference data
water+alpha-D-glucosyl-(1->4)-alpha-D-mannose2D-glucose
Reaction pageLeft to rightBalancedEC 3.2.1.20cytosol
Human-GEM MAR08587CC BY 4.0Reference data
water+alpha-maltotrioseD-glucose+alpha-D-glucosyl-(1->4)-alpha-D-mannose
Reaction pageLeft to rightBalancedEC 3.2.1.20cytosol
Human-GEM MAR08591CC BY 4.0Reference data
MAM01678c+waterMAM01677c+D-glucose
Catalysed by SI or KANSL3 or MGAM
Reaction pageLeft to rightBalancedEC 3.2.1.3, 3.2.1.10cytosol
Human-GEM MAR09464CC BY 4.0Reference data
D-maltotriose+watermaltose+alpha-D-glucose
Catalysed by MGAM
Reaction pageLeft to rightBalanced
Rhea RHEA:27970CC BY 4.0Reference data
D-maltotetraose+waterD-maltotriose+alpha-D-glucose
Catalysed by MGAM
Reaction pageLeft to rightBalanced
Rhea RHEA:29631CC BY 4.0Reference data
D-maltopentaose+waterD-maltotetraose+alpha-D-glucose
Catalysed by MGAM
Reaction pageLeft to rightBalanced
Rhea RHEA:29635CC BY 4.0Reference data
D-maltohexaose+waterD-maltopentaose+alpha-D-glucose
Catalysed by MGAM
Reaction pageLeft to rightBalanced
Rhea RHEA:29639CC BY 4.0Reference data
D-maltoheptaose+waterD-maltohexaose+alpha-D-glucose
Catalysed by MGAM
Reaction pageLeft to rightBalanced
Rhea RHEA:29643CC BY 4.0Reference data
maltose+wateralpha-D-glucose+D-glucose
Reaction pageLeft to rightBalanced
Rhea RHEA:68796CC BY 4.0Reference data