NLRP14

Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (By similarity). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive. Also plays a role in spermatogenesis by regulating differentiation of primordial germ cell-like cells, possibly by protecting HSPA2 from proteasome-mediated degradation (By similarity)..

Function from UniProtKB (Q86W24), read 2026-09-23. CC BY 4.0.