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Proteins/UNIPROT:P48050

KCNJ4

Protein·UNIPROT:P48050Inward rectifier potassium channel 41 compound

Open in the graph

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium..

Function from UniProtKB (P48050), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

K(+)ElementCHEBI:29103Inferred only14 paths14 endpoints

What the reference databases state

Statements

35 statements

35 statements · 4 reference databases · Subject: KCNJ4 · Sources: Bgee, Hetionet, Reactome, Rhea

Search this listOrder

KCNJ4 covaries with TMEM151AProteinHetionet hetionet:covaries:256472-3761Inferred only
UCHL1 covaries with KCNJ4ProteinHetionet hetionet:covaries:3761-7345Inferred only
KCNJ4 is expressed in apex of heartAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in Brodmann (1909) area 10AnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in Brodmann (1909) area 23AnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in Brodmann (1909) area 46AnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in CA1 field of hippocampusAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in endothelial cellCell typeBgee ENSG00000168135Inferred only
KCNJ4 is expressed in entorhinal cortexAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in frontal poleAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in middle temporal gyrusAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in parietal lobeAnatomyBgee ENSG00000168135Inferred only

Show the remaining 23

KCNJ4 is expressed in postcentral gyrusAnatomyBgee ENSG00000168135Inferred only
KCNJ4 is expressed in superior frontal gyrusAnatomyBgee ENSG00000168135Inferred only
DLG2 interacts with KCNJ4ProteinHetionet hetionet:interacts:1740-3761Inferred only
GNGT2 interacts with KCNJ4ProteinHetionet hetionet:interacts:2793-3761Inferred only
IL16 interacts with KCNJ4ProteinHetionet hetionet:interacts:3603-3761Inferred only
KCNJ4 interacts with LIN7BProteinHetionet hetionet:interacts:3761-64130Inferred only
KCNJ4 interacts with SNTA1ProteinHetionet hetionet:interacts:3761-6640Inferred only
KCNJ4 participates in Activation of G protein gated Potassium channelsPathwayReactome R-HSA-1296041Inferred only
KCNJ4 participates in Activation of GABAB receptorsPathwayReactome R-HSA-991365Inferred only
KCNJ4 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
KCNJ4 participates in Classical Kir channelsPathwayReactome R-HSA-1296053Inferred only
KCNJ4 participates in G protein gated Potassium channelsPathwayReactome R-HSA-1296059Inferred only
KCNJ4 participates in GABA B receptor activationPathwayReactome R-HSA-977444Inferred only
KCNJ4 participates in GABA receptor activationPathwayReactome R-HSA-977443Inferred only
KCNJ4 participates in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsPathwayReactome R-HSA-997272Inferred only
KCNJ4 participates in Inwardly rectifying K+ channelsPathwayReactome R-HSA-1296065Inferred only
KCNJ4 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
KCNJ4 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
KCNJ4 participates in Neurotransmitter receptors and postsynaptic signal transmissionPathwayReactome R-HSA-112314Inferred only
KCNJ4 participates in Phase 4 - resting membrane potentialPathwayReactome R-HSA-5576886Inferred only
KCNJ4 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
KCNJ4 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
K(+) is transported by KCNJ4CompoundRhea RHEA:29463Inferred only

Reactions

1 reaction

K(+)K(+)
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data

Other names

8 names

Resolves to: KCNJ4

Also called: Hippocampal inward rectifierHIRHIRK2HRK1Inward rectifier K(+) channel Kir2.3IRK-3IRK3Potassium channel, inwardly rectifying subfamily J member 4

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