Pathway
Phase 4 - resting membrane potential
Phase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+ and relatively impermeable to other ions therefore the K+ gradient across the cell membrane is the key determinant in the normal resting potential. In this phase, K+ currents are generated by inward rectifier potassium channels (KCNJs) and tandem pore domain K+ channels (KCNKs). Some Na+/K+-ATPases and Na+/Ca2+-exchangers can also play roles during this phase.
REACT:R-HSA-5576886Reactome
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: Phase 4 - resting membrane potential · Sources: Reactome
- KCNJ12 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNJ14 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNJ2 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNJ4 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK1 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK10 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK12 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK13 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK15 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK16 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK17 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK18 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
Show the remaining 7
- KCNK2 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK3 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK4 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK5 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK6 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK7 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only
- KCNK9 participates in Phase 4 - resting membrane potentialProteinReactome R-HSA-5576886Inferred only