Loading the page.
Proteins/UNIPROT:Q14005
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
[Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Function from UniProtKB (Q14005), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
49 statements
49 statements · 4 reference databases · Subject: IL16 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
4 names
Resolves to: IL16