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Proteins/UNIPROT:Q9H5X1

CIAO2A

Protein·UNIPROT:Q9H5X1

Open in the graph

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1..

Function from UniProtKB (Q9H5X1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 2 reference databases · Subject: CIAO2A · Sources: Hetionet, WikiPathways

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KCNH6 covaries with CIAO2AProteinHetionet hetionet:covaries:81033-84191Inferred only
CIAO1 interacts with CIAO2AProteinHetionet hetionet:interacts:84191-9391Inferred only
UBC interacts with CIAO2AProteinHetionet hetionet:interacts:7316-84191Inferred only
CIAO2A participates in 2q11 2 copy number variation syndromePathwayWikiPathways WP5221Inferred only
CIAO2A participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
CIAO2A participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
CIAO2A participates in miR targeted genes in squamous cellPathwayWikiPathways WP2006Inferred only

Other names

4 names

Resolves to: CIAO2A

Also called: CIA2ACytosolic iron-sulfur assembly component 2AFAM96AMIP18 family protein FAM96A

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