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Proteins/UNIPROT:Q8WVZ9
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex..
Function from UniProtKB (Q8WVZ9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
70 statements
70 statements · 3 reference databases · Subject: KBTBD7 · Sources: gene ontology, Hetionet, Reactome
1 name
Resolves to: KBTBD7