Proteins/UNIPROT:Q9Y2Y6

TMEM98

ProteinUNIPROT:Q9Y2Y6

Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1)..

Function from UniProtKB (Q9Y2Y6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

nanophthalmia has a germline basis in TMEM98DiseaseGenCC HGNC:24529|MONDO:0005514Inferred only
nanophthalmos 4 has a germline basis in TMEM98DiseaseGenCC HGNC:24529|MONDO:0014426Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: TMEM98 · Sources: gene ontology, Hetionet, WikiPathways

Order

TMEM98 covaries with KBTBD7ProteinHetionet hetionet:covaries:26022-84078Inferred only
OR2B2 covaries with TMEM98ProteinHetionet hetionet:covaries:26022-81697Inferred only
PDLIM7 covaries with TMEM98ProteinHetionet hetionet:covaries:26022-9260Inferred only
RABEPK interacts with TMEM98ProteinHetionet hetionet:interacts:10244-26022Inferred only
TNNT1 interacts with TMEM98ProteinHetionet hetionet:interacts:26022-7138Inferred only
UBC interacts with TMEM98ProteinHetionet hetionet:interacts:26022-7316Inferred only
TMEM98 participates in Kallmann syndromePathwayWikiPathways WP5074Inferred only
TMEM98 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
TMEM98 regulates negative regulation of myelinationBiological processgene ontology Q9Y2Y6|GO:0031642Inferred only
TMEM98 regulates negative regulation of oligodendrocyte differentiationBiological processgene ontology Q9Y2Y6|GO:0048715Inferred only
TMEM98 regulates negative regulation of protein localization to nucleusBiological processgene ontology Q9Y2Y6|GO:1900181Inferred only
TMEM98 regulates negative regulation of protein processingBiological processgene ontology Q9Y2Y6|GO:0010955Inferred only

Other names

2 names

Resolves to: TMEM98

Also called: Protein TADA1Transmembrane protein 98

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