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Proteins/UNIPROT:O95096

NKX2-2

Protein·UNIPROT:O95096

Open in the graph

Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity)..

Function from UniProtKB (O95096), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

monogenic diabetes has a germline basis in NKX2-2DiseaseGenCC HGNC:7835|MONDO:0015967Inferred only
neonatal diabetes mellitus has a germline basis in NKX2-2DiseaseGenCC HGNC:7835|MONDO:0016391Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: NKX2-2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

ABCA2 covaries with NKX2-2ProteinHetionet hetionet:covaries:20-4821Inferred only
ADAP1 covaries with NKX2-2ProteinHetionet hetionet:covaries:11033-4821Inferred only
NKX2-2 covaries with DDR2ProteinHetionet hetionet:covaries:4821-4921Inferred only
GABBR1 covaries with NKX2-2ProteinHetionet hetionet:covaries:2550-4821Inferred only
NKX2-2 covaries with HOXB7ProteinHetionet hetionet:covaries:3217-4821Inferred only
NKX2-2 covaries with KAT5ProteinHetionet hetionet:covaries:10524-4821Inferred only
NKX2-2 covaries with KBTBD7ProteinHetionet hetionet:covaries:4821-84078Inferred only
KCTD1 covaries with NKX2-2ProteinHetionet hetionet:covaries:284252-4821Inferred only
NKX2-2 covaries with NR4A2ProteinHetionet hetionet:covaries:4821-4929Inferred only
NKX2-2 covaries with OTX1ProteinHetionet hetionet:covaries:4821-5013Inferred only
RASGRP2 covaries with NKX2-2ProteinHetionet hetionet:covaries:10235-4821Inferred only
NKX2-2 covaries with RPS6KA4ProteinHetionet hetionet:covaries:4821-8986Inferred only

Show the remaining 16

SAR1A covaries with NKX2-2ProteinHetionet hetionet:covaries:4821-56681Inferred only
TRIM39-RPP21 covaries with NKX2-2ProteinHetionet hetionet:covaries:202658-4821Inferred only
VPS11 covaries with NKX2-2ProteinHetionet hetionet:covaries:4821-55823Inferred only
NKX2-2 covaries with XAB2ProteinHetionet hetionet:covaries:4821-56949Inferred only
NKX2-2 covaries with ZNF423ProteinHetionet hetionet:covaries:23090-4821Inferred only
NKX2-2 interacts with OLIG2ProteinHetionet hetionet:interacts:10215-4821Inferred only
NKX2-2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NKX2-2 participates in Dopaminergic neurogenesisPathwayWikiPathways WP2855Inferred only
NKX2-2 participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
NKX2-2 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
NKX2-2 participates in Oligodendrocyte specification and differentiation leading to myelin components for CNSPathwayWikiPathways WP4304Inferred only
NKX2-2 participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
NKX2-2 participates in Regulation of gene expression in beta cellsPathwayReactome R-HSA-210745Inferred only
NKX2-2 participates in Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cellsPathwayReactome R-HSA-210746Inferred only
NKX2-2 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
NKX2-2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O95096|GO:0006357Inferred only

Other names

4 names

Resolves to: NKX2-2

Also called: Homeobox protein NK-2 homolog BHomeobox protein Nkx-2.2NKX2.2NKX2B

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