Proteins/UNIPROT:Q5SZK8

FREM2

ProteinUNIPROT:Q5SZK8

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs..

Function from UniProtKB (Q5SZK8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

Fraser syndrome has a germline basis in FREM2DiseaseGenCC HGNC:25396|MONDO:0009046Inferred only
Fraser syndrome 1 has a germline basis in FREM2DiseaseGenCC HGNC:25396|MONDO:0054737Inferred only
Fraser syndrome 2 has a germline basis in FREM2DiseaseGenCC HGNC:25396|MONDO:0054738Inferred only
renal agenesis, unilateral has a germline basis in FREM2DiseaseGenCC HGNC:25396|MONDO:0019636Inferred only

Statements

19 statements

19 statements · 2 reference databases · Subject: FREM2 · Sources: Hetionet, WikiPathways

Order

BTN2A2 covaries with FREM2ProteinHetionet hetionet:covaries:10385-341640Inferred only
DHX30 covaries with FREM2ProteinHetionet hetionet:covaries:22907-341640Inferred only
FZD3 covaries with FREM2ProteinHetionet hetionet:covaries:341640-7976Inferred only
FREM2 covaries with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:covaries:121504-341640Inferred only
IGFBP7 covaries with FREM2ProteinHetionet hetionet:covaries:341640-3490Inferred only
FREM2 covaries with ITGA8ProteinHetionet hetionet:covaries:341640-8516Inferred only
FREM2 covaries with KRTAP5-5ProteinHetionet hetionet:covaries:341640-439915Inferred only
LAMTOR4 covaries with FREM2ProteinHetionet hetionet:covaries:341640-389541Inferred only
MPG covaries with FREM2ProteinHetionet hetionet:covaries:341640-4350Inferred only
NAPSA covaries with FREM2ProteinHetionet hetionet:covaries:341640-9476Inferred only
NCALD covaries with FREM2ProteinHetionet hetionet:covaries:341640-83988Inferred only
NTF4 covaries with FREM2ProteinHetionet hetionet:covaries:341640-4909Inferred only

Show the remaining 7

RAB3A covaries with FREM2ProteinHetionet hetionet:covaries:341640-5864Inferred only
FREM2 covaries with RPL21ProteinHetionet hetionet:covaries:341640-6144Inferred only
SORBS2 covaries with FREM2ProteinHetionet hetionet:covaries:341640-8470Inferred only
FREM2 covaries with STARD13ProteinHetionet hetionet:covaries:341640-90627Inferred only
TMEM203 covaries with FREM2ProteinHetionet hetionet:covaries:341640-94107Inferred only
TMUB1 covaries with FREM2ProteinHetionet hetionet:covaries:341640-83590Inferred only
FREM2 participates in Development of ureteric derived collecting systemPathwayWikiPathways WP5053Inferred only

Other names

2 names

Resolves to: FREM2

Also called: ECM3 homologFRAS1-related extracellular matrix protein 2

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