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Proteins/UNIPROT:Q6UXI9

NPNT

Protein·UNIPROT:Q6UXI9

Open in the graph

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)..

Function from UniProtKB (Q6UXI9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

renal agenesis has a germline basis in NPNTDiseaseGenCC HGNC:27405|MONDO:0018470Inferred only

Statements

10 statements

10 statements · 3 reference databases · Subject: NPNT · Sources: gene ontology, Hetionet, Reactome

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NPNT covaries with FLOT1ProteinHetionet hetionet:covaries:10211-255743Inferred only
NPNT covaries with TMEM160ProteinHetionet hetionet:covaries:255743-54958Inferred only
ITGA8 interacts with NPNTProteinHetionet hetionet:interacts:255743-8516Inferred only
NPNT participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NPNT participates in Formation of the nephric ductPathwayReactome R-HSA-9830364Inferred only
NPNT participates in Formation of the ureteric budPathwayReactome R-HSA-9830674Inferred only
NPNT participates in Kidney developmentPathwayReactome R-HSA-9830369Inferred only
NPNT regulates positive regulation of cell-substrate adhesionBiological processgene ontology Q6UXI9|GO:0010811Inferred only
NPNT regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q6UXI9|GO:0070374Inferred only
NPNT regulates positive regulation of osteoblast differentiationBiological processgene ontology Q6UXI9|GO:0045669Inferred only

Other names

5 names

Resolves to: NPNT

Also called: EGFL6-likeEGFL6LPOEMPreosteoblast EGF-like repeat protein with MAM domainProtein EGFL6-like

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