Proteins/UNIPROT:Q9H0C8

ILKAP

ProteinUNIPROT:Q9H0C8

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation..

Function from UniProtKB (Q9H0C8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 3 reference databases · Subject: ILKAP · Sources: Hetionet, UniProt, WikiPathways

Order

ZNF623 covaries with ILKAPProteinHetionet hetionet:covaries:80895-9831Inferred only
HGS interacts with ILKAPProteinHetionet hetionet:interacts:80895-9146Inferred only
ILK interacts with ILKAPProteinHetionet hetionet:interacts:3611-80895Inferred only
UBC interacts with ILKAPProteinHetionet hetionet:interacts:7316-80895Inferred only
ILKAP participates in 2q37 copy number variation syndromePathwayWikiPathways WP5224Inferred only
ILKAP requires the cofactor magnesium(2+)CompoundUniProt Q9H0C8Inferred only
ILKAP requires the cofactor Mn(2+)CompoundUniProt Q9H0C8Inferred only

Reactions

2 reactions

O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives
Reaction pageLeft to rightBalance undeterminable

← Every protein Find it in the graph →

Rhea RHEA:20629

CC BY 4.0

Reference data

O-phospho-L-threonyl-[protein]+waterL-threonyl-[protein]+hydrogenphosphate

Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 59 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:47004CC BY 4.0Reference data