Proteins/UNIPROT:P16871

IL7R

ProteinUNIPROT:P16871

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Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Function from UniProtKB (P16871), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

immunodeficiency 104 has a germline basis in IL7RDiseaseGenCC HGNC:6024|MONDO:0012163Inferred only
Omenn syndrome has a germline basis in IL7RDiseaseGenCC HGNC:6024|MONDO:0011338Inferred only
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency has a germline basis in IL7RDiseaseGenCC HGNC:6024|MONDO:0015701Inferred only

Statements

52 statements

52 statements · 4 reference databases · Subject: IL7R · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

IL7R covaries with ZNF26ProteinHetionet hetionet:covaries:3575-7574Inferred only
CBL interacts with IL7RProteinHetionet hetionet:interacts:3575-867Inferred only
IL7R interacts with CRLF2ProteinHetionet hetionet:interacts:3575-64109Inferred only
FYN interacts with IL7RProteinHetionet hetionet:interacts:2534-3575Inferred only
IL2RG interacts with IL7RProteinHetionet hetionet:interacts:3561-3575Inferred only
IL7 interacts with IL7RProteinHetionet hetionet:interacts:3574-3575Inferred only
IL7R interacts with JAK1ProteinHetionet hetionet:interacts:3575-3716Inferred only
IL7R interacts with JAK3ProteinHetionet hetionet:interacts:3575-3718Inferred only
IL7R interacts with LYNProteinHetionet hetionet:interacts:3575-4067Inferred only
IL7R interacts with PIK3R1ProteinHetionet hetionet:interacts:3575-5295Inferred only
PTK2B interacts with IL7RProteinHetionet hetionet:interacts:2185-3575Inferred only
IL7R interacts with RAD21ProteinHetionet hetionet:interacts:3575-5885Inferred only

Show the remaining 40

IL7R interacts with STAT3ProteinHetionet hetionet:interacts:3575-6774Inferred only
IL7R interacts with STAT5AProteinHetionet hetionet:interacts:3575-6776Inferred only
IL7R interacts with STAT5BProteinHetionet hetionet:interacts:3575-6777Inferred only
IL7R interacts with TSLPProteinHetionet hetionet:interacts:3575-85480Inferred only
IL7R interacts with UBCProteinHetionet hetionet:interacts:3575-7316Inferred only
IL7R participates in Apoptosis related network due to altered Notch3 in ovarian cancerPathwayWikiPathways WP2864Inferred only
IL7R participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
IL7R participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
IL7R participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
IL7R participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL7R participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL7R participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
IL7R participates in FOXP3 in COVID 19PathwayWikiPathways WP5063Inferred only
IL7R participates in IL7 signalingPathwayWikiPathways WP205Inferred only
IL7R participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL7R participates in Interleukin-7 signalingPathwayReactome R-HSA-1266695Inferred only
IL7R participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
IL7R participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
IL7R participates in Regulatory circuits of STAT3 signalingPathwayWikiPathways WP4538Inferred only
IL7R participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL7R participates in Thymic stromal lymphopoietin TSLP signalingPathwayWikiPathways WP2203Inferred only
IL7R participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
IL7R regulates negative regulation of apoptotic processBiological processgene ontology P16871|GO:0043066Inferred only
IL7R regulates negative regulation of Fas signaling pathwayBiological processgene ontology P16871|GO:1902045Inferred only
IL7R regulates negative regulation of tyrosine phosphorylation of STAT proteinBiological processgene ontology P16871|GO:0042532Inferred only
IL7R regulates positive regulation of cell population proliferationBiological processgene ontology P16871|GO:0008284Inferred only
IL7R regulates positive regulation of receptor signaling pathway via JAK-STATBiological processgene ontology P16871|GO:0046427Inferred only
IL7R regulates positive regulation of receptor signaling pathway via STATBiological processgene ontology P16871|GO:1904894Inferred only
IL7R regulates positive regulation of T cell differentiationBiological processgene ontology P16871|GO:0045582Inferred only
IL7R regulates regulation of DNA recombinationBiological processgene ontology P16871|GO:0000018Inferred only
IL7R increases the expression of IKZF1ProteinHetionet hetionet:regulates:3575-10320Inferred only
IL7R decreases the expression of KLHDC2ProteinHetionet hetionet:regulates:3575-23588Inferred only
IL7R decreases the expression of PIK3C2BProteinHetionet hetionet:regulates:3575-5287Inferred only
IL7R decreases the expression of PPP2R5EProteinHetionet hetionet:regulates:3575-5529Inferred only
IL7R decreases the expression of PSMD9ProteinHetionet hetionet:regulates:3575-5715Inferred only
IL7R increases the expression of RRP8ProteinHetionet hetionet:regulates:3575-23378Inferred only
IL7R increases the expression of SATB1ProteinHetionet hetionet:regulates:3575-6304Inferred only
IL7R decreases the expression of SLC35B1ProteinHetionet hetionet:regulates:3575-10237Inferred only
IL7R increases the expression of TLR4ProteinHetionet hetionet:regulates:3575-7099Inferred only
IL7R increases the expression of WIF1ProteinHetionet hetionet:regulates:3575-11197Inferred only

Other names

6 names

Resolves to: IL7R

Also called: CD antigen CD127CDw127IL-7 receptor subunit alphaIL-7R subunit alphaIL-7R-alphaIL-7RA

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