Proteins/UNIPROT:Q5GLZ8

HERC4

ProteinUNIPROT:Q5GLZ8

Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates..

Function from UniProtKB (Q5GLZ8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: HERC4 · Sources: gene ontology, Hetionet, Reactome

Order

DACT3 covaries with HERC4ProteinHetionet hetionet:covaries:147906-26091Inferred only
OR2V2 covaries with HERC4ProteinHetionet hetionet:covaries:26091-285659Inferred only
ZNF585A covaries with HERC4ProteinHetionet hetionet:covaries:199704-26091Inferred only
HERC4 interacts with HERC6ProteinHetionet hetionet:interacts:26091-55008Inferred only
HSP90AA1 interacts with HERC4ProteinHetionet hetionet:interacts:26091-3320Inferred only
HSP90AB1 interacts with HERC4ProteinHetionet hetionet:interacts:26091-3326Inferred only
UBC interacts with HERC4ProteinHetionet hetionet:interacts:26091-7316Inferred only
UBE2D2 interacts with HERC4ProteinHetionet hetionet:interacts:26091-7322Inferred only
UBE2E3 interacts with HERC4ProteinHetionet hetionet:interacts:10477-26091Inferred only
HERC4 interacts with UBE2J2ProteinHetionet hetionet:interacts:118424-26091Inferred only
HERC4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
HERC4 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only

Show the remaining 6

HERC4 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
HERC4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
HERC4 regulates negative regulation of smoothened signaling pathwayBiological processgene ontology Q5GLZ8|GO:0045879Inferred only
ARG1 increases the expression of HERC4ProteinHetionet hetionet:regulates:383-26091Inferred only
STAMBP increases the expression of HERC4ProteinHetionet hetionet:regulates:10617-26091Inferred only
TENT4A increases the expression of HERC4ProteinHetionet hetionet:regulates:11044-26091Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

3 names

Resolves to: HERC4

Also called: HECT domain and RCC1-like domain-containing protein 4HECT-type E3 ubiquitin transferase HERC4KIAA1593

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