Biological process
negative regulation of smoothened signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
Definition from the Gene Ontology (GO:0045879), read 2026-09-23. CC BY 4.0.
GO:0045879Gene Ontology
What the reference databases state
Statements
29 statements
29 statements · 1 reference database · Subject: negative regulation of smoothened signaling pathway · Sources: gene ontology
- BTRC regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9Y297|GO:0045879Inferred only
- GLI3 regulates negative regulation of smoothened signaling pathwayProteingene ontology P10071|GO:0045879Inferred only
- GLIS2 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9BZE0|GO:0045879Inferred only
- GPC3 regulates negative regulation of smoothened signaling pathwayProteingene ontology P51654|GO:0045879Inferred only
- GPR161 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q8N6U8|GO:0045879Inferred only
- GSK3B regulates negative regulation of smoothened signaling pathwayProteingene ontology P49841|GO:0045879Inferred only
- HERC4 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q5GLZ8|GO:0045879Inferred only
- HHIP regulates negative regulation of smoothened signaling pathwayProteingene ontology Q96QV1|GO:0045879Inferred only
- IFT122 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9HBG6|GO:0045879Inferred only
- KCTD1 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q719H9|GO:0045879Inferred only
- KCTD21 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q4G0X4|GO:0045879Inferred only
- KCTD6 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q8NC69|GO:0045879Inferred only
Show the remaining 17
- KIF7 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q2M1P5|GO:0045879Inferred only
- MEGF8 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q7Z7M0|GO:0045879Inferred only
- MGRN1 regulates negative regulation of smoothened signaling pathwayProteingene ontology O60291|GO:0045879Inferred only
- MOSMO regulates negative regulation of smoothened signaling pathwayProteingene ontology Q8NHV5|GO:0045879Inferred only
- NCOA2 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q15596|GO:0045879Inferred only
- PRKACA regulates negative regulation of smoothened signaling pathwayProteingene ontology P17612|GO:0045879Inferred only
- PRKAR1A regulates negative regulation of smoothened signaling pathwayProteingene ontology P10644|GO:0045879Inferred only
- PRKCD regulates negative regulation of smoothened signaling pathwayProteingene ontology Q05655|GO:0045879Inferred only
- PTCH1 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q13635|GO:0045879Inferred only
- PTCH2 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9Y6C5|GO:0045879Inferred only
- RAB23 regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9ULC3|GO:0045879Inferred only
- RACK1 regulates negative regulation of smoothened signaling pathwayProteingene ontology P63244|GO:0045879Inferred only
- RBX1 regulates negative regulation of smoothened signaling pathwayProteingene ontology P62877|GO:0045879Inferred only
- SUFU regulates negative regulation of smoothened signaling pathwayProteingene ontology Q9UMX1|GO:0045879Inferred only
- TULP3 regulates negative regulation of smoothened signaling pathwayProteingene ontology O75386|GO:0045879Inferred only
- UBR5 regulates negative regulation of smoothened signaling pathwayProteingene ontology O95071|GO:0045879Inferred only
- VCP regulates negative regulation of smoothened signaling pathwayProteingene ontology P55072|GO:0045879Inferred only