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Proteins/UNIPROT:Q6MZM0

HEPHL1

Protein·UNIPROT:Q6MZM0Ferroxidase HEPHL1

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Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intracellular iron content..

Function from UniProtKB (Q6MZM0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

4 statements

4 statements · 3 reference databases · Subject: HEPHL1 · Sources: Rhea, UniProt, WikiPathways

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HEPHL1 participates in Iron metabolism in placentaPathwayWikiPathways WP2007Inferred only
HEPHL1 requires the cofactor copper cationCompoundUniProt Q6MZM0Inferred only
Fe(3+) is a substrate of HEPHL1CompoundRhea RHEA:11148Inferred only
iron(2+) is a substrate of HEPHL1CompoundRhea RHEA:11148Inferred only

Reactions

1 reaction

4iron(2+)+dioxygen+4hydron4Fe(3+)+2water
Catalysed by CP or FTH1 or FXN or HEPHL1 or FTMT or HEPH
Reaction pageReversibleBalanced
Rhea RHEA:11148CC BY 4.0Reference data

Other names

1 name

Resolves to: HEPHL1

Also called: Hephaestin-like protein 1

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