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Proteins/UNIPROT:Q68DV7
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)..
Function from UniProtKB (Q68DV7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
22 statements
22 statements · 3 reference databases · Subject: RNF43 · Sources: gene ontology, Hetionet, Reactome
2 names
Resolves to: RNF43