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Proteins/UNIPROT:O00219
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis..
Function from UniProtKB (O00219), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 8 reference databases · Subject: HAS3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
4 reactions
UDP-alpha-D-glucuronate+CHEBI:162642proton+MAM02139e+2UDP
Catalysed by HAS3 or HAS1 or HAS2
Reaction pageLeft to rightBalancedEC 2.4.1.212cytosol, extracellular space
Human-GEM MAR07568CC BY 4.0Reference data
MAM02139e+UDP-alpha-D-glucuronate+CHEBI:162642proton+
3 names
Resolves to: HAS3
Reaction pageLeft to rightBalancedEC 2.4.1.212extracellular space, cytosol
Human-GEM MAR07569CC BY 4.0Reference data
N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)+UDP-alpha-D-glucuronate[hyaluronan](n+1)+UDP+hydron
Catalysed by HAS3 or HAS2 or HAS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12528CC BY 4.0Reference data
[hyaluronan](n)+UDP-N-acetyl-alpha-D-glucosamineN-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)+UDP+hydron
Catalysed by HAS3 or HAS2 or HAS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20465CC BY 4.0Reference data