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Proteins/UNIPROT:Q92819
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)..
Function from UniProtKB (Q92819), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 5 reference databases · Subject: HAS2 · Sources: gene ontology, Human-GEM, Reactome, Rhea, UniProt
4 reactions
UDP-alpha-D-glucuronate+CHEBI:162642proton+MAM02139e+2UDP
Catalysed by HAS3 or HAS1 or HAS2
Reaction pageLeft to rightBalancedEC 2.4.1.212cytosol, extracellular space
Human-GEM MAR07568CC BY 4.0Reference data
MAM02139e+UDP-alpha-D-glucuronate+CHEBI:162642proton+
3 names
Resolves to: HAS2
Reaction pageLeft to rightBalancedEC 2.4.1.212extracellular space, cytosol
Human-GEM MAR07569CC BY 4.0Reference data
N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)+UDP-alpha-D-glucuronate[hyaluronan](n+1)+UDP+hydron
Catalysed by HAS3 or HAS2 or HAS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12528CC BY 4.0Reference data
[hyaluronan](n)+UDP-N-acetyl-alpha-D-glucosamineN-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)+UDP+hydron
Catalysed by HAS3 or HAS2 or HAS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20465CC BY 4.0Reference data