Proteins/UNIPROT:Q6ZVN8

HJV

ProteinUNIPROT:Q6ZVN8

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis..

Function from UniProtKB (Q6ZVN8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

hemochromatosis type 2 has a germline basis in HJVDiseaseGenCC HGNC:4887|MONDO:0019257Inferred only
hemochromatosis type 2A has a germline basis in HJVDiseaseGenCC HGNC:4887|MONDO:0011216Inferred only

Statements

12 statements

12 statements · 4 reference databases · Subject: HJV · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ANK2 covaries with HJVProteinHetionet hetionet:covaries:148738-287Inferred only
H2AC21 covaries with HJVProteinHetionet hetionet:covaries:148738-317772Inferred only
KCTD3 covaries with HJVProteinHetionet hetionet:covaries:148738-51133Inferred only
HJV participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
HJV participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
HJV participates in Hfe effect on hepcidin productionPathwayWikiPathways WP3924Inferred only
HJV participates in Iron metabolism disordersPathwayWikiPathways WP5172Inferred only
HJV participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
HJV participates in Netrin-1 signalingPathwayReactome R-HSA-373752Inferred only
HJV participates in TAR syndromePathwayWikiPathways WP5362Inferred only
HJV regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q6ZVN8|GO:0000122Inferred only
HJV regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q6ZVN8|GO:0045944Inferred only

Other names

5 names

Resolves to: HJV

Also called: Hemochromatosis type 2 proteinHemojuvelin BMP coreceptorHFE2RGM domain family member CRGMC

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