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Proteins/UNIPROT:Q15842
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity)..
Function from UniProtKB (Q15842), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
19 statements
19 statements · 6 reference databases · Subject: KCNJ8 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Transported by ABCC8 & KCNJ8 or ABCC9 & KCNJ8 or ABCC8 & KCNJ11 or ABCC9 & KCNJ11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05433CC BY 4.0Reference data
3 names
Resolves to: KCNJ8
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data