Proteins/UNIPROT:O75420

GIGYF1

ProteinUNIPROT:O75420

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity)..

Function from UniProtKB (O75420), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autism spectrum disorder has a germline basis in GIGYF1DiseaseGenCC HGNC:9126|MONDO:0005258Inferred only
complex neurodevelopmental disorder has a germline basis in GIGYF1DiseaseGenCC HGNC:9126|MONDO:0100038Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: GIGYF1 · Sources: gene ontology, Hetionet, WikiPathways

Order

AATK covaries with GIGYF1ProteinHetionet hetionet:covaries:64599-9625Inferred only
GIGYF1 covaries with AIREProteinHetionet hetionet:covaries:326-64599Inferred only
GIGYF1 covaries with BEND3ProteinHetionet hetionet:covaries:57673-64599Inferred only
GIGYF1 covaries with C1QTNF9ProteinHetionet hetionet:covaries:338872-64599Inferred only
GIGYF1 covaries with CBFA2T3ProteinHetionet hetionet:covaries:64599-863Inferred only
CCDC9 covaries with GIGYF1ProteinHetionet hetionet:covaries:26093-64599Inferred only
HOXC12 covaries with GIGYF1ProteinHetionet hetionet:covaries:3228-64599Inferred only
NANOG covaries with GIGYF1ProteinHetionet hetionet:covaries:64599-79923Inferred only
GIGYF1 covaries with PCLAFProteinHetionet hetionet:covaries:64599-9768Inferred only
GIGYF1 covaries with RPL17-C18orf32ProteinHetionet hetionet:covaries:100526842-64599Inferred only
GIGYF1 covaries with SCG2ProteinHetionet hetionet:covaries:64599-7857Inferred only
GIGYF1 covaries with ZNF215ProteinHetionet hetionet:covaries:64599-7762Inferred only

Show the remaining 5

ATN1 interacts with GIGYF1ProteinHetionet hetionet:interacts:1822-64599Inferred only
EIF4E2 interacts with GIGYF1ProteinHetionet hetionet:interacts:64599-9470Inferred only
GRB10 interacts with GIGYF1ProteinHetionet hetionet:interacts:2887-64599Inferred only
GIGYF1 participates in KCNQ2 and KCNQ3 related epilepsyPathwayWikiPathways WP5599Inferred only
GIGYF1 regulates negative regulation of translational initiationBiological processgene ontology O75420|GO:0045947Inferred only

Other names

4 names

Resolves to: GIGYF1

Also called: CDS2GRB10-interacting GYF protein 1PERQ amino acid-rich with GYF domain-containing protein 1PERQ1

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