Proteins/UNIPROT:Q5T5X7

BEND3

ProteinUNIPROT:Q5T5X7

Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities..

Function from UniProtKB (Q5T5X7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: BEND3 · Sources: gene ontology, Hetionet

Order

CCDC9 covaries with BEND3ProteinHetionet hetionet:covaries:26093-57673Inferred only
GIGYF1 covaries with BEND3ProteinHetionet hetionet:covaries:57673-64599Inferred only
BEND3 covaries with PLIN5ProteinHetionet hetionet:covaries:440503-57673Inferred only
BEND3 covaries with ZNF215ProteinHetionet hetionet:covaries:57673-7762Inferred only
BARD1 interacts with BEND3ProteinHetionet hetionet:interacts:57673-580Inferred only
SIRT7 interacts with BEND3ProteinHetionet hetionet:interacts:51547-57673Inferred only
SUMO2 interacts with BEND3ProteinHetionet hetionet:interacts:57673-6613Inferred only
UBC interacts with BEND3ProteinHetionet hetionet:interacts:57673-7316Inferred only
BEND3 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q5T5X7|GO:0000122Inferred only
BEND3 regulates positive regulation of ATP metabolic processBiological processgene ontology Q5T5X7|GO:1903580Inferred only

Other names

2 names

Resolves to: BEND3

Also called: BEN domain-containing protein 3KIAA1553

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