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Proteins/UNIPROT:Q8IXK2
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Function from UniProtKB (Q8IXK2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 4 reference databases · Subject: GALNT12 · Sources: Hetionet, Reactome, Rhea, UniProt
4 reactions
5 names
Resolves to: GALNT12
Human-GEM MAR01353CC BY 4.0Reference data
MAM00205g+MAM03110gproton+MAM03000g+UDP
Catalysed by GALNT16 or GALNT7 or GALNT18 or GALNT3 or GALNT12 or GALNT8 or GALNT15 or GALNT5 or GALNT6 or GALNT1 or GALNT2 or GALNT13 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.41Golgi apparatus
Human-GEM MAR07436CC BY 4.0Reference data
L-seryl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+UDP+hydron
Catalysed by GALNT2 or GALNT1 or GALNT3 or GALNT17 or GALNT18 or GALNT5 or GALNT7 or GALNT10 or GALNT13 or GALNT12 or GALNT15 or GALNT16 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23956CC BY 4.0Reference data
L-threonyl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+UDP+hydron
Catalysed by GALNT2 or GALNT1 or GALNT3 or GALNT17 or GALNT18 or GALNT5 or GALNT7 or GALNT10 or GALNT13 or GALNT12 or GALNT15 or GALNT16 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52424CC BY 4.0Reference data