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Proteins/UNIPROT:Q8IUC8
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor. Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures. Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity)..
[Isoform 1]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain..
[Isoform 4]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13)..
Function from UniProtKB (Q8IUC8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 4 reference databases · Subject: GALNT13 · Sources: Hetionet, Reactome, Rhea, UniProt
4 reactions
6 names
Resolves to: GALNT13
Human-GEM MAR01353CC BY 4.0Reference data
MAM00205g+MAM03110gproton+MAM03000g+UDP
Catalysed by GALNT16 or GALNT7 or GALNT18 or GALNT3 or GALNT12 or GALNT8 or GALNT15 or GALNT5 or GALNT6 or GALNT1 or GALNT2 or GALNT13 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.41Golgi apparatus
Human-GEM MAR07436CC BY 4.0Reference data
L-seryl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+UDP+hydron
Catalysed by GALNT2 or GALNT1 or GALNT3 or GALNT17 or GALNT18 or GALNT5 or GALNT7 or GALNT10 or GALNT13 or GALNT12 or GALNT15 or GALNT16 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23956CC BY 4.0Reference data
L-threonyl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+UDP+hydron
Catalysed by GALNT2 or GALNT1 or GALNT3 or GALNT17 or GALNT18 or GALNT5 or GALNT7 or GALNT10 or GALNT13 or GALNT12 or GALNT15 or GALNT16 and 6 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52424CC BY 4.0Reference data