open-angle glaucoma
MONDO:0005338Mondo
Findings
No curated finding names open-angle glaucoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.
Definition from the Mondo Disease Ontology (MONDO:0005338), read 2026-09-29. CC BY 4.0.
Genes
4 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MYOCHGNC:7610
- Definitive · ClinGen · Autosomal dominant · 2022
- EFEMP1HGNC:3218
- Moderate · ClinGen · Autosomal dominant · 2024
- RAMP2HGNC:9844
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- Limited · Ambry Genetics · Autosomal dominant · 2020
- TP53BP2HGNC:12000
- Disputed Evidence · ClinGen · Autosomal dominant · 2023
Where it sits
- A kind of
Other names
5 names
Resolves to: open-angle glaucoma
- Also called
- glaucoma, primary open angleopen angle glaucomapigmentary glaucomaPOAGprimary open angle glaucoma