striate palmoplantar keratoderma
Findings
No curated finding names striate palmoplantar keratoderma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Striate palmoplantar keratoderma is an isolated, focal, hereditary palmoplantar keratoderma characterized by linear hyperkeratosis along the flexor aspect of the fingers and on palms, as well as focal hyperkeratosis of the plantar skin. Patients present with painful thickening of the skin on palms and soles, with occasional fissuring, blistering and hyperhidrosis. Rarely, hyperkeratosis on other areas may be seen (knees, dorsal aspects of the digits). Histopatologically, widened intercellular spaces between keratinocytes are observed.
Definition from the Mondo Disease Ontology (MONDO:0018865), read 2026-09-29. CC BY 4.0.
Features
3 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Palmoplantar keratodermaHPOHP:0000982
- Very frequent (80% to 99% of cases)
- Abnormal hair morphologyHPOHP:0001595
- Frequent (30% to 79% of cases)
- Abnormal nail morphologyHPOHP:0001597
- Frequent (30% to 79% of cases)
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
- Narrower terms (2)
Other names
3 names
Resolves to: striate palmoplantar keratoderma
- Also called
- keratosis palmoplantaris striatakeratosis palmoplantaris striata et areatakeratosis palmoplantaris varians of Wachters