spinocerebellar ataxia type 37
Findings
No curated finding names spinocerebellar ataxia type 37 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Spinocerebellar ataxia type 37 (SCA37) is a subtype of autosomal dominant cerebellar ataxia type 1 (ADCA type 1), characterized by a cerebellar syndrome along with altered vertical eye movements.
Definition from the Mondo Disease Ontology (MONDO:0014410), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Juvenile onset · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AtaxiaHPOHP:0001251
- 27 of 27 reported patients
- DysarthriaHPOHP:0001260
- 27 of 30 reported patients
- Abnormal conjugate eye movementHPOHP:0000549
- Very frequent (80% to 99% of cases)
- Cogwheel rigidityHPOHP:0002396
- Very frequent (80% to 99% of cases)
- FallsHPOHP:0002527
- Very frequent (80% to 99% of cases)
- Abnormal speech patternHPOHP:0002167
- Frequent (30% to 79% of cases)
- Cerebellar vermis atrophyHPO
Show the remaining 7
- MyoclonusHPOHP:0001336
- Frequent (30% to 79% of cases)
- Scanning speechHPOHP:0002168
- Frequent (30% to 79% of cases)
- Sensorineural hearing impairmentHPOHP:0000407
- Frequent (30% to 79% of cases)
- Somatic sensory dysfunctionHPOHP:0003474
- Frequent (30% to 79% of cases)
- TremorHPOHP:0001337
- Frequent (30% to 79% of cases)
- Truncal ataxiaHPOHP:0002078
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- DAB1HGNC:2661
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
- Limited · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
Where it sits
Other names
2 names
Resolves to: spinocerebellar ataxia type 37
- Also called
- SCA37spinocerebellar ataxia with altered vertical eye movements