Proteins/UNIPROT:P51671

CCL11

ProteinUNIPROT:P51671

Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells. Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway..

Function from UniProtKB (P51671), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

36 statements

36 statements · 4 reference databases · Subject: CCL11 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACKR2 interacts with CCL11ProteinHetionet hetionet:interacts:1238-6356Inferred only
CCL11 interacts with ACKR4ProteinHetionet hetionet:interacts:51554-6356Inferred only
CCL2 interacts with CCL11ProteinHetionet hetionet:interacts:6347-6356Inferred only
CCL11 interacts with CCR2ProteinHetionet hetionet:interacts:6356-729230Inferred only
CCR3 interacts with CCL11ProteinHetionet hetionet:interacts:1232-6356Inferred only
CCR5 interacts with CCL11ProteinHetionet hetionet:interacts:1234-6356Inferred only
CXCR3 interacts with CCL11ProteinHetionet hetionet:interacts:2833-6356Inferred only
DPP4 interacts with CCL11ProteinHetionet hetionet:interacts:1803-6356Inferred only
NFKB1 interacts with CCL11ProteinHetionet hetionet:interacts:4790-6356Inferred only
CCL11 interacts with NUDT3ProteinHetionet hetionet:interacts:11165-6356Inferred only
CCL11 interacts with TPI1ProteinHetionet hetionet:interacts:6356-7167Inferred only
CCL11 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only

Show the remaining 24

CCL11 participates in Blood based neuroinflammation markers PathwayWikiPathways WP5548Inferred only
CCL11 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CCL11 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
CCL11 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCL11 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
CCL11 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
CCL11 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CCL11 participates in IL19 signalingPathwayWikiPathways WP5422Inferred only
CCL11 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CCL11 participates in Interleukin-4 and Interleukin-13 signalingPathwayReactome R-HSA-6785807Inferred only
CCL11 participates in Lung fibrosisPathwayWikiPathways WP3624Inferred only
CCL11 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CCL11 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
CCL11 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCL11 participates in Post COVID neuroinflammationPathwayWikiPathways WP5485Inferred only
CCL11 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCL11 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCL11 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
CCL11 regulates negative regulation of neurogenesisBiological processgene ontology P51671|GO:0050768Inferred only
CCL11 regulates positive regulation of actin filament polymerizationBiological processgene ontology P51671|GO:0030838Inferred only
CCL11 regulates positive regulation of angiogenesisBiological processgene ontology P51671|GO:0045766Inferred only
CCL11 regulates positive regulation of cell migrationBiological processgene ontology P51671|GO:0030335Inferred only
CCL11 regulates positive regulation of endothelial cell proliferationBiological processgene ontology P51671|GO:0001938Inferred only
CCL11 regulates regulation of cell shapeBiological processgene ontology P51671|GO:0008360Inferred only

Other names

4 names

Resolves to: CCL11

Also called: C-C motif chemokine 11Eosinophil chemotactic proteinSCYA11Small-inducible cytokine A11

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