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Proteins/UNIPROT:P20908

COL5A1

Protein·UNIPROT:P20908

Open in the graph

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

Function from UniProtKB (P20908), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

Ehlers-Danlos syndrome has a germline basis in COL5A1DiseaseGenCC HGNC:2209|MONDO:0020066Inferred only
Ehlers-Danlos syndrome, classic type has a germline basis in COL5A1DiseaseGenCC HGNC:2209|MONDO:0007522Inferred only
Ehlers-Danlos syndrome, classic type, 1 has a germline basis in COL5A1DiseaseGenCC HGNC:2209|MONDO:0019567Inferred only

Statements

56 statements

56 statements · 4 reference databases · Subject: COL5A1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

COL5A1 covaries with GABPB1ProteinHetionet hetionet:covaries:1289-2553Inferred only
COL5A1 covaries with ING5ProteinHetionet hetionet:covaries:1289-84289Inferred only
ITPR1 covaries with COL5A1ProteinHetionet hetionet:covaries:1289-3708Inferred only
COL5A1 covaries with PROK1ProteinHetionet hetionet:covaries:1289-84432Inferred only
COL5A1 covaries with YTHDF1ProteinHetionet hetionet:covaries:1289-54915Inferred only
COL5A1 interacts with COL5A2ProteinHetionet hetionet:interacts:1289-1290Inferred only
COL5A1 interacts with COL5A3ProteinHetionet hetionet:interacts:1289-50509Inferred only
COL5A1 interacts with DCNProteinHetionet hetionet:interacts:1289-1634Inferred only
COL5A1 interacts with LGALS3BPProteinHetionet hetionet:interacts:1289-3959Inferred only
COL5A1 interacts with MAGProteinHetionet hetionet:interacts:1289-4099Inferred only
COL5A1 interacts with SDC3ProteinHetionet hetionet:interacts:1289-9672Inferred only
COL5A1 interacts with SIRT7ProteinHetionet hetionet:interacts:1289-51547Inferred only

Show the remaining 44

COL5A1 interacts with SPARCProteinHetionet hetionet:interacts:1289-6678Inferred only
COL5A1 interacts with THBS1ProteinHetionet hetionet:interacts:1289-7057Inferred only
COL5A1 interacts with UBCProteinHetionet hetionet:interacts:1289-7316Inferred only
COL5A1 participates in Allograft rejectionPathwayWikiPathways WP2328Inferred only
COL5A1 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
COL5A1 participates in Attachment of bacteria to epithelial cellsPathwayReactome R-HSA-9638630Inferred only
COL5A1 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
COL5A1 participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
COL5A1 participates in Biofilm formationPathwayReactome R-HSA-9931953Inferred only
COL5A1 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
COL5A1 participates in Collagen chain trimerizationPathwayReactome R-HSA-8948216Inferred only
COL5A1 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
COL5A1 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
COL5A1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
COL5A1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
COL5A1 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
COL5A1 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
COL5A1 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
COL5A1 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
COL5A1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
COL5A1 participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
COL5A1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
COL5A1 participates in Fibronectin matrix formationPathwayReactome R-HSA-1566977Inferred only
COL5A1 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
COL5A1 participates in Infection with EnterobacteriaPathwayReactome R-HSA-9640148Inferred only
COL5A1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
COL5A1 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only
COL5A1 participates in MET activates PTK2 signalingPathwayReactome R-HSA-8874081Inferred only
COL5A1 participates in MET promotes cell motilityPathwayReactome R-HSA-8875878Inferred only
COL5A1 participates in miR 509 3p alteration of YAP1 ECM axisPathwayWikiPathways WP3967Inferred only
COL5A1 participates in miRNA targets in ECM and membrane receptorsPathwayWikiPathways WP2911Inferred only
COL5A1 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
COL5A1 participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
COL5A1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
COL5A1 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
COL5A1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
COL5A1 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
COL5A1 participates in Signaling by PDGFPathwayReactome R-HSA-186797Inferred only
COL5A1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
COL5A1 participates in Syndecan interactionsPathwayReactome R-HSA-3000170Inferred only
COL5A1 regulates negative regulation of endodermal cell differentiationBiological processgene ontology P20908|GO:1903225Inferred only
EBF1 increases the expression of COL5A1ProteinHetionet hetionet:regulates:1879-1289Inferred only
LOXL1 decreases the expression of COL5A1ProteinHetionet hetionet:regulates:4016-1289Inferred only
TIMP2 decreases the expression of COL5A1ProteinHetionet hetionet:regulates:7077-1289Inferred only

Other names

2 names

Resolves to: COL5A1

Also called: Collagen alpha-1V

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