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Proteins/UNIPROT:P05997

COL5A2

Protein·UNIPROT:P05997

Open in the graph

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity)..

Function from UniProtKB (P05997), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

Ehlers-Danlos syndrome has a germline basis in COL5A2DiseaseGenCC HGNC:2210|MONDO:0020066Inferred only
Ehlers-Danlos syndrome, classic type has a germline basis in COL5A2DiseaseGenCC HGNC:2210|MONDO:0007522Inferred only
Ehlers-Danlos syndrome, classic type, 2 has a germline basis in COL5A2DiseaseGenCC HGNC:2210|MONDO:0019568Inferred only

Statements

44 statements

44 statements · 4 reference databases · Subject: COL5A2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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COL5A2 interacts with COL11A1ProteinHetionet hetionet:interacts:1290-1301Inferred only
COL5A1 interacts with COL5A2ProteinHetionet hetionet:interacts:1289-1290Inferred only
DDR1 interacts with COL5A2ProteinHetionet hetionet:interacts:1290-780Inferred only
COL5A2 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
COL5A2 participates in Attachment of bacteria to epithelial cellsPathwayReactome R-HSA-9638630Inferred only
COL5A2 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
COL5A2 participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
COL5A2 participates in Biofilm formationPathwayReactome R-HSA-9931953Inferred only
COL5A2 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
COL5A2 participates in Collagen chain trimerizationPathwayReactome R-HSA-8948216Inferred only
COL5A2 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
COL5A2 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only

Show the remaining 32

COL5A2 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
COL5A2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
COL5A2 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
COL5A2 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
COL5A2 participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
COL5A2 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
COL5A2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
COL5A2 participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
COL5A2 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
COL5A2 participates in Fibronectin matrix formationPathwayReactome R-HSA-1566977Inferred only
COL5A2 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
COL5A2 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
COL5A2 participates in Infection with EnterobacteriaPathwayReactome R-HSA-9640148Inferred only
COL5A2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
COL5A2 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only
COL5A2 participates in MET activates PTK2 signalingPathwayReactome R-HSA-8874081Inferred only
COL5A2 participates in MET promotes cell motilityPathwayReactome R-HSA-8875878Inferred only
COL5A2 participates in miRNA targets in ECM and membrane receptorsPathwayWikiPathways WP2911Inferred only
COL5A2 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
COL5A2 participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
COL5A2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
COL5A2 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
COL5A2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
COL5A2 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
COL5A2 participates in Signaling by PDGFPathwayReactome R-HSA-186797Inferred only
COL5A2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
COL5A2 participates in Syndecan interactionsPathwayReactome R-HSA-3000170Inferred only
COL5A2 regulates negative regulation of endodermal cell differentiationBiological processgene ontology P05997|GO:1903225Inferred only
FOXA3 increases the expression of COL5A2ProteinHetionet hetionet:regulates:3171-1290Inferred only
MLXIP increases the expression of COL5A2ProteinHetionet hetionet:regulates:22877-1290Inferred only
MOK increases the expression of COL5A2ProteinHetionet hetionet:regulates:5891-1290Inferred only
TIMP1 increases the expression of COL5A2ProteinHetionet hetionet:regulates:7076-1290Inferred only

Other names

2 names

Resolves to: COL5A2

Also called: Collagen alpha-2V

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