Pathway
Gap junction degradation
The half-life of Cx is very short (1 to 5h) compared to other junctional proteins. Connexins are targeted for degradation by the proteasome and the lysosome. Degradation appears to involve the phosphorylation of Connexins as well as their interactions with other proteins.
REACT:R-HSA-190873Reactome
What the reference databases state
Statements
12 statements
12 statements · 1 reference database · Subject: Gap junction degradation · Sources: Reactome
- ACTB participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- ACTG1 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- AP2M1 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- CLTA participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- CLTB participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- CLTC participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- CLTCL1 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- DAB2 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- DNM1 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- DNM2 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- GJA1 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only
- MYO6 participates in Gap junction degradationProteinReactome R-HSA-190873Inferred only