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Proteins/UNIPROT:Q00526
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner..
Function from UniProtKB (Q00526), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
40 statements
40 statements · 2 reference databases · Subject: CDK3 · Sources: gene ontology, Hetionet
2 reactions
2 names
Resolves to: CDK3
Rhea RHEA:17989CC BY 4.0Reference data