ADAM33

Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation. Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG. Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways. Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades..

Function from UniProtKB (Q9BZ11), read 2026-09-23. CC BY 4.0.