Proteins/UNIPROT:P30988

CALCR

ProteinUNIPROT:P30988

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway..

[Isoform 2]: Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding..

Function from UniProtKB (P30988), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 4 reference databases · Subject: CALCR · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CALCA interacts with CALCRProteinHetionet hetionet:interacts:796-799Inferred only
CALCR interacts with CALM1ProteinHetionet hetionet:interacts:799-805Inferred only
CALCR interacts with CALM1ProteinHetionet hetionet:interacts:799-801Inferred only
CALCR interacts with CALM1ProteinHetionet hetionet:interacts:799-808Inferred only
CALCR interacts with FLNAProteinHetionet hetionet:interacts:2316-799Inferred only
CALCR interacts with GPRASP2ProteinHetionet hetionet:interacts:114928-799Inferred only
CALCR interacts with LRP1ProteinHetionet hetionet:interacts:4035-799Inferred only
CALCR interacts with MBL2ProteinHetionet hetionet:interacts:4153-799Inferred only
CALCR interacts with RAMP1ProteinHetionet hetionet:interacts:10267-799Inferred only
CALCR interacts with RAMP3ProteinHetionet hetionet:interacts:10268-799Inferred only
CALCR interacts with THBS1ProteinHetionet hetionet:interacts:7057-799Inferred only
CALCR interacts with TOPBP1ProteinHetionet hetionet:interacts:11073-799Inferred only

Show the remaining 15

CALCR interacts with TSHRProteinHetionet hetionet:interacts:7253-799Inferred only
CALCR participates in Calcitonin-like ligand receptorsPathwayReactome R-HSA-419812Inferred only
CALCR participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
CALCR participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
CALCR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CALCR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CALCR participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
CALCR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CALCR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CALCR regulates positive regulation of calcium-mediated signalingBiological processgene ontology P30988|GO:0050850Inferred only
CALCR regulates positive regulation of cAMP/PKA signal transductionBiological processgene ontology P30988|GO:0141163Inferred only
CALCR regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P30988|GO:0007204Inferred only
CALCR regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology P30988|GO:0070374Inferred only
CALCR regulates positive regulation of gene expressionBiological processgene ontology P30988|GO:0010628Inferred only
CALCR regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P30988|GO:0051897Inferred only

Other names

2 names

Resolves to: CALCR

Also called: Calcitonin receptorCT-R

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