Pathway
PI3K events in ERBB4 signaling
The CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1. Binding of PIK3R1 to CYT1 isoforms of ERBB4 is followed by recruitment of the p110 catalytic subunit of PI3K (PIK3CA), leading to assembly of an active PI3K complex that converts PIP2 to PIP3 and activates AKT signaling.
REACT:R-HSA-1250342Reactome
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: PI3K events in ERBB4 signaling · Sources: Reactome
- BTC participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- EREG participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- HBEGF participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- NRG1 participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- NRG2 participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- NRG3 participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- NRG4 participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- PIK3CA participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only
- PIK3R1 participates in PI3K events in ERBB4 signalingProteinReactome R-HSA-1250342Inferred only