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Proteins/UNIPROT:Q8NBU5
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity)..
Function from UniProtKB (Q8NBU5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
17 statements
17 statements · 4 reference databases · Subject: ATAD1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
[protein]-with a C-terminal TM segment+ATP(4-)+water[protein]-with a C-terminal TM segment+ADP(3-)+hydrogenphosphate+hydron
Transported by ATAD1 or ATP13A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66168CC BY 4.0Reference data
3 names
Resolves to: ATAD1