Proteins/UNIPROT:Q92765

FRZB

ProteinUNIPROT:Q92765

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

Function from UniProtKB (Q92765), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: FRZB · Sources: gene ontology, Hetionet, WikiPathways

Order

ARHGEF28 covaries with FRZBProteinHetionet hetionet:covaries:2487-64283Inferred only
FRZB covaries with FLG2ProteinHetionet hetionet:covaries:2487-388698Inferred only
FRZB interacts with BBS10ProteinHetionet hetionet:interacts:2487-79738Inferred only
FRZB interacts with EHFProteinHetionet hetionet:interacts:2487-26298Inferred only
ELF5 interacts with FRZBProteinHetionet hetionet:interacts:2001-2487Inferred only
FRZB interacts with PNO1ProteinHetionet hetionet:interacts:2487-56902Inferred only
FRZB interacts with POLA2ProteinHetionet hetionet:interacts:23649-2487Inferred only
FRZB interacts with RBX1ProteinHetionet hetionet:interacts:2487-9978Inferred only
FRZB interacts with SMAD1ProteinHetionet hetionet:interacts:2487-4086Inferred only
FRZB participates in AdipogenesisPathwayWikiPathways WP236Inferred only
FRZB participates in Endochondral ossificationPathwayWikiPathways WP474Inferred only
FRZB participates in Endochondral ossification with skeletal dysplasiasPathwayWikiPathways WP4808Inferred only

Show the remaining 7

FRZB participates in Hepatitis C and hepatocellular carcinomaPathwayWikiPathways WP3646Inferred only
FRZB regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q92765|GO:0090090Inferred only
FRZB regulates negative regulation of cell growthBiological processgene ontology Q92765|GO:0030308Inferred only
FRZB regulates negative regulation of cell population proliferationBiological processgene ontology Q92765|GO:0008285Inferred only
FRZB regulates negative regulation of Wnt signaling pathwayBiological processgene ontology Q92765|GO:0030178Inferred only
FRZB regulates positive regulation of apoptotic processBiological processgene ontology Q92765|GO:0043065Inferred only
FRZB regulates positive regulation of fat cell differentiationBiological processgene ontology Q92765|GO:0045600Inferred only

Other names

10 names

Resolves to: FRZB

Also called: FIZFREFrezzledFritzFrizzled-related protein 1FRPFrzB-1FRZB1sFRP-3SFRP3

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