Proteins/UNIPROT:P26374

CHML

ProteinUNIPROT:P26374

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family..

Function from UniProtKB (P26374), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: CHML · Sources: Hetionet, Reactome, WikiPathways

Order

ARHGEF25 covaries with CHMLProteinHetionet hetionet:covaries:1122-115557Inferred only
GRID2IP covaries with CHMLProteinHetionet hetionet:covaries:1122-392862Inferred only
CHML covaries with MAN1C1ProteinHetionet hetionet:covaries:1122-57134Inferred only
ZNF45 covaries with CHMLProteinHetionet hetionet:covaries:1122-7596Inferred only
CHML interacts with RAB1AProteinHetionet hetionet:interacts:1122-5861Inferred only
CHML interacts with RAB3AProteinHetionet hetionet:interacts:1122-5864Inferred only
CHML interacts with RAB5AProteinHetionet hetionet:interacts:1122-5868Inferred only
CHML interacts with RAB6AProteinHetionet hetionet:interacts:1122-5870Inferred only
CHML interacts with RABGGTBProteinHetionet hetionet:interacts:1122-5876Inferred only
CHML interacts with UBCProteinHetionet hetionet:interacts:1122-7316Inferred only
CHML participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
CHML participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only

Show the remaining 6

CHML participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CHML participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CHML participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
CHML participates in RAB geranylgeranylationPathwayReactome R-HSA-8873719Inferred only
CHML participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
CHML participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

4 names

Resolves to: CHML

Also called: Choroideremia-like proteinRab escort protein 2REP-2REP2

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