Proteins/UNIPROT:P23508

MCC

ProteinUNIPROT:P23508

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity..

Function from UniProtKB (P23508), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 2 reference databases · Subject: MCC · Sources: gene ontology, Hetionet

Order

ABO covaries with MCCProteinHetionet hetionet:covaries:28-4163Inferred only
MCC covaries with DCHS2ProteinHetionet hetionet:covaries:4163-54798Inferred only
MCC covaries with HEPN1ProteinHetionet hetionet:covaries:4163-641654Inferred only
IQCC covaries with MCCProteinHetionet hetionet:covaries:4163-55721Inferred only
MCC covaries with LCE4AProteinHetionet hetionet:covaries:199834-4163Inferred only
PDZRN4 covaries with MCCProteinHetionet hetionet:covaries:29951-4163Inferred only
MCC covaries with RANProteinHetionet hetionet:covaries:4163-5901Inferred only
MCC covaries with RPS15ProteinHetionet hetionet:covaries:4163-6209Inferred only
MCC covaries with SPTBN5ProteinHetionet hetionet:covaries:4163-51332Inferred only
ZSCAN9 covaries with MCCProteinHetionet hetionet:covaries:4163-7746Inferred only
MCC interacts with NFKBIBProteinHetionet hetionet:interacts:4163-4793Inferred only
MCC regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology P23508|GO:0090090Inferred only

Show the remaining 2

MCC regulates negative regulation of epithelial cell migrationBiological processgene ontology P23508|GO:0010633Inferred only
MCC regulates negative regulation of epithelial cell proliferationBiological processgene ontology P23508|GO:0050680Inferred only

Other names

2 names

Resolves to: MCC

Also called: Colorectal mutant cancer proteinProtein MCC

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