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Proteins/UNIPROT:Q9H6I2

SOX17

Protein·UNIPROT:Q9H6I2

Open in the graph

Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells..

Function from UniProtKB (Q9H6I2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

familial vesicoureteral reflux has a germline basis in SOX17DiseaseGenCC HGNC:18122|MONDO:0017329Inferred only
pulmonary arterial hypertension has a germline basis in SOX17DiseaseGenCC HGNC:18122|MONDO:0015924Inferred only
vesicoureteral reflux 3 has a germline basis in SOX17DiseaseGenCC HGNC:18122|MONDO:0013356Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: SOX17 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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SOX17 covaries with DMPKProteinHetionet hetionet:covaries:1760-64321Inferred only
SOX17 covaries with GRM6ProteinHetionet hetionet:covaries:2916-64321Inferred only
PTGS1 covaries with SOX17ProteinHetionet hetionet:covaries:5742-64321Inferred only
TMEM215 covaries with SOX17ProteinHetionet hetionet:covaries:401498-64321Inferred only
CTNNB1 interacts with SOX17ProteinHetionet hetionet:interacts:1499-64321Inferred only
SOX17 participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
SOX17 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
SOX17 participates in Deactivation of the beta-catenin transactivating complexPathwayReactome R-HSA-3769402Inferred only
SOX17 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SOX17 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
SOX17 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
SOX17 participates in Developmental Lineage of Multipotent Pancreatic Progenitor CellsPathwayReactome R-HSA-9937080Inferred only

Show the remaining 23

SOX17 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
SOX17 participates in Formation of definitive endodermPathwayReactome R-HSA-9823730Inferred only
SOX17 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
SOX17 participates in GDNF RET signaling axisPathwayWikiPathways WP4830Inferred only
SOX17 participates in lncRNA in canonical Wnt signaling and colorectal cancerPathwayWikiPathways WP4258Inferred only
SOX17 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
SOX17 participates in ncRNAs in Wnt signaling in hepatocellular carcinomaPathwayWikiPathways WP4336Inferred only
SOX17 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
SOX17 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
SOX17 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SOX17 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
SOX17 participates in Specification of primordial germ cellsPathwayReactome R-HSA-9827857Inferred only
SOX17 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
SOX17 participates in Wnt signalingPathwayWikiPathways WP428Inferred only
SOX17 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q9H6I2|GO:0090090Inferred only
SOX17 regulates negative regulation of cell growthBiological processgene ontology Q9H6I2|GO:0030308Inferred only
SOX17 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q9H6I2|GO:0045893Inferred only
SOX17 regulates positive regulation of protein catabolic processBiological processgene ontology Q9H6I2|GO:0045732Inferred only
SOX17 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9H6I2|GO:0045944Inferred only
SOX17 regulates regulation of cardiac cell fate specificationBiological processgene ontology Q9H6I2|GO:2000043Inferred only
SOX17 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9H6I2|GO:0006355Inferred only
SOX17 regulates regulation of embryonic developmentBiological processgene ontology Q9H6I2|GO:0045995Inferred only
SOX17 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9H6I2|GO:0006357Inferred only

Other names

2 names

Resolves to: SOX17

Also called: SOX-17Transcription factor SOX-17

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