Papers/PMID:33712024
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.
Nutrition journal2021The record
3 findings · 1 compound · 3 endpoints · 3 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
3 findings
Vitis vinifera — no detected effect on malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“According to the meta-analysis of seven RCTs, GPCP had no significant impact on MDA levels (WMD = − 0.178 μmol/L; 95% CI: − 0.46, 0.11; P = 0.22).”
Quoted verbatim from The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in seven pooled randomized trials of grape products containing polyphenols (grape extract, grape powder, juice, raisin, resveratrol, red wine), healthy and unhealthy participants combined
Effect -0.178 mean difference, 95% CI -0.46 to 0.11
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.2021PMID:33712024Industry fundedPermalink
Vitis vinifera — no detected effect on glutathione peroxidase activity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Meta-analysis of five RCTs showed no significant effect of GPCP on GPX levels (WMD = 0.026 U/mgHb; 95% CI: − 0.002, 0.05; P = 0.07).”
Quoted verbatim from The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in five pooled randomized trials of grape products containing polyphenols (grape extract, grape powder, juice, raisin, resveratrol, red wine), healthy and unhealthy participants combined
Effect 0.026 mean difference, 95% CI -0.002 to 0.05
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.2021PMID:33712024Industry fundedPermalink
Vitis vinifera — no detected effect on superoxide dismutase activity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“According to the data meta-analysis, some studies showed that GPCP had no significant effect on SOD levels (WMD = 0.003 U/mgHb; 95% CI: − 0.002, 0.007; P = 0.29).”
Quoted verbatim from The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in pooled randomized trials of grape products containing polyphenols (grape extract, grape powder, juice, raisin, resveratrol, red wine), healthy and unhealthy participants combined
Effect 0.003 mean difference, 95% CI -0.002 to 0.007
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.2021PMID:33712024Industry fundedPermalink