Papers/PMID:37683291
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.
Canadian journal of physiology and pharmacology2024The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
astaxanthin — decreases serum creatinine concentration
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Also, AST significantly reduced the amount of creatinine, urea, and uric acid in the serum and improved the activity of SOD and catalase in the kidney tissue (p < 0.05).”
Quoted verbatim from Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 25, 50, or 75 mg/kg astaxanthin during the 10-day course, alongside MTX 10 mg/kg on days 6, 8, 10
- Population
- male Wistar rats with methotrexate-induced nephrotoxicity
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.2024PMID:37683291Permalink
astaxanthin — decreases serum uric acid
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Also, AST significantly reduced the amount of creatinine, urea, and uric acid in the serum and improved the activity of SOD and catalase in the kidney tissue (p < 0.05).”
Quoted verbatim from Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 25, 50, or 75 mg/kg astaxanthin during the 10-day course, alongside MTX 10 mg/kg on days 6, 8, 10
- Population
- male Wistar rats with methotrexate-induced nephrotoxicity
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.2024PMID:37683291Permalink