Papers/PMID:8212059
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.
Toxicology letters1993The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
sodium benzoate — increases gamma-glutamyl transferase
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In male rats of the 2.4% group, relative liver and kidney weight, serum levels of albumin, total protein and gamma-glutamyl transpeptidase were significantly increased and enlarged hepatocytes with glassy cytoplasm were seen using light microscopy.”
Quoted verbatim from Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 2.4% sodium benzoate in diet
- Population
- male F344 rats, 2.4% sodium benzoate in diet for 10 days
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.1993PMID:8212059Permalink
sodium benzoate — increases serum albumin
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In male rats of the 2.4% group, relative liver and kidney weight, serum levels of albumin, total protein and gamma-glutamyl transpeptidase were significantly increased and enlarged hepatocytes with glassy cytoplasm were seen using light microscopy.”
Quoted verbatim from Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 2.4% sodium benzoate in diet
- Population
- male F344 rats, 2.4% sodium benzoate in diet for 10 days
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.1993PMID:8212059Permalink
sodium benzoate — increases total cholesterol (TC)
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In male mice of the 3.0% group, absolute liver weights and serum cholesterol and phospholipid levels were significantly increased, and enlargement, vacuolation and necrosis of hepatocytes were evident.”
Quoted verbatim from Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 3.0% sodium benzoate in diet
- Population
- male B6C3F1 mice, 3.0% sodium benzoate in diet for 10 days
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.1993PMID:8212059Permalink