Papers/PMID:21798674
Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.
Drug and alcohol dependence2012The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
trazodone — no detected effect on pittsburgh Sleep Quality Index global score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For example, between baseline and 1-month, mean PSQI scores decreased 2.9 and 3.9 points among those randomized to placebo and trazodone, respectively; the difference in mean change was not significant (p =.145).”
Quoted verbatim from Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 50 mg capsules, 1-3 at bedtime as needed, 50-150 mg
- Population
- Methadone-maintained adults with sleep complaints (baseline PSQI of 6 or higher); trazodone 50 mg capsules self-titrated at bedtime to 50-150 mg, against identical placebo capsules, for one month; all received a sleep hygiene brochure
Trazodone for sleep disturbance during methadone maintenance: a double-blind, placebo-controlled trial.2012PMID:21798674Permalink