Papers/PMID:30277579
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.
The Cochrane database of systematic reviews2018The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
Ca(2+) — decreases preterm birth incidence
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“The average risk of preterm birth was reduced in the calcium supplementation group (11 trials, 15,275 women: RR 0.76, 95% CI 0.60 to 0.97; I² = 60%; low-quality evidence); this reduction was greatest amongst women at higher risk of developing pre-eclampsia (four trials, 568 women: average RR 0.45, 95% CI 0.24 to 0.83; I² = 60%).”
Quoted verbatim from Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.. - Study
- meta-analysis
- Participants
- 15,275
- Dose
- at least 1 g/day calcium during pregnancy
- Population
- Pregnant women; high-dose calcium supplementation (at least 1 g daily) versus placebo, pooled RCTs; whole-population estimate
Effect 0.76 risk ratio, 95% CI 0.6 to 0.97
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.2018PMID:30277579Permalink
Ca(2+) — decreases pre-eclampsia incidence
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“There was also a reduction in the risk of pre-eclampsia associated with calcium supplementation (13 trials, 15,730 women: average RR 0.45, 95% CI 0.31 to 0.65; I² = 70%; low-quality evidence).”
Quoted verbatim from Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.. - Study
- meta-analysis
- Participants
- 15,730
- Dose
- at least 1 g/day calcium during pregnancy
- Population
- Pregnant women; high-dose calcium supplementation (at least 1 g daily) versus placebo, pooled RCTs
Effect 0.45 risk ratio, 95% CI 0.31 to 0.65
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.2018PMID:30277579Permalink