Papers/PMID:35418570
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
Nutrition & diabetes2022The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-leucine — decreases body weight gain over a feeding or growth period
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Feeding of HFMP and HFL resulted in a lower body weight gain compared to HF due to a reduced fat mass accumulation.”
Quoted verbatim from Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.. - Study
- animal · not in humans
- Duration
- 5 months
- Dose
- 50 g/kg diet L-leucine
- Population
- Male C57BL/6JRj mice on a 40 energy% high-fat diet; HFL arm is the high-fat diet with 50 g/kg L-leucine added, compared with unsupplemented high-fat diet (both 140 g/kg casein); 20-week feeding
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.2022PMID:35418570Permalink