Papers/PMID:16179085
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].
Malaria journal2005The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
methylene blue — no detected effect on blood haemoglobin concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There were no differences between CQ and CQ-MB study groups in haemoglobin and haematocrit values over time in both the G6PD deficient and sufficient subgroups (Table 3).”
Quoted verbatim from Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].. - Study
- RCT
- Duration
- 14 days
- Dose
- 0.5% MB solution 4 mg/kg/day for three days, plus chloroquine 25 mg/kg over three days
- Population
- children aged 6-59 months with uncomplicated falciparum malaria, Burkina Faso; chloroquine given to both arms; result stated for G6PD deficient and G6PD sufficient subgroups
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].2005PMID:16179085Permalink
methylene blue — no detected effect on haematocrit
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There were no differences between CQ and CQ-MB study groups in haemoglobin and haematocrit values over time in both the G6PD deficient and sufficient subgroups (Table 3).”
Quoted verbatim from Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].. - Study
- RCT
- Duration
- 14 days
- Dose
- 0.5% MB solution 4 mg/kg/day for three days, plus chloroquine 25 mg/kg over three days
- Population
- children aged 6-59 months with uncomplicated falciparum malaria, Burkina Faso; chloroquine given to both arms; result stated for G6PD deficient and G6PD sufficient subgroups
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].2005PMID:16179085Permalink