a 3-oxoacyl-CoA

Three steps

• 1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 more

• (3E)-decenoyl-CoAReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 7 moremitochondrial matrix

• 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 2 morecytosol, endoplasmic reticulumOne of 6 routes

• N-tetradecanoylglycineReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 5 moremitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• N-docosanoylglycineReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• N-hexacosanoylglycineReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 1 morecytosol

• (2E,5Z)-tetradecadienoyl-CoAReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 morecytosol, mitochondrial matrixOne of 4 routes

• (2E,7Z)-hexadecadienoyl-CoAReach from here →
  1. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  2. acyl-CoA pool formation and breakdown
  3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)

  Catalysed by ACAA1, SCP2, ACAA2, HADHB and 4 morecytosol, mitochondrial matrixOne of 4 routes